東京工業大学 大隅研究室

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Publication List

2024

• Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast.
  Isoda T, Takeda E, Hosokawa S, Hotta-Ren S, Ohsumi Y.
  iScience., 2024 Apr 26;27(6):109810. doi: 10.1016/j.isci.2024.109810.
  
  Receptor-mediated cargo hitchhiking on bulk autophagy.
  Takeda E, Isoda T, Hosokawa S, Oikawa Y, Hotta-Ren S, May AI, Ohsumi Y
  EMBO J., 2024 May 16, 43, 3116-3140 doi: 10.1038/s44318-024-00091-8
  

2023

• The mechanism of Atg15-mediated membrane disruption in autophagy.
  Kagohashi Y, Sasaki M, May AI, Kawamata T, Ohsumi Y.
  J Cell Biol., 2023 Dec 4;222(12):e202306120. doi: 10.1083/jcb.202306120. Epub 2023 Nov 2.
  Press release:Tokyo Institute of Technology.
  
  A mechanism that ensures non-selective cytoplasm degradation by autophagy.
  Kotani T, Sakai Y, Kirisako H, Kakuta C, Kakuta S, Ohsumi Y, Nakatogawa H.
  Nat Commun., 2023 Sep 19;14(1):5815. doi: 10.1038/s41467-023-41525-x.
  

2022

• Bur1 functions with TORC1 for vacuole-mediated cell cycle progression.
  Jin Y, Jin N, Oikawa Y, Benyair R, Koizumi M, Wilson TE, Ohsumi Y, Weisman LS.
  EMBO Rep., 2022 Feb 15:e53477 Epub ahead of print.
  

• A method for the isolation and characterization of autophagic bodies from yeast provides a key tool to investigate cargos of autophagy
  Kawamata T, Makino S, Kagohashi Y, Sasaki M, Ohsumi Y.
  J. Biol. Chem, Available online 25 October 2022, 102641.
  

2021

• Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis
  Maruyama T, Alam JM, Fukuda T, Kageyama S, Kirisako H, Ishii Y, Shimada I, Ohsumi Y, Komatsu M, Kanki T, Nakatogawa H, Noda NN.
  Nat Struct Mol Biol., 2021 Jul;28(7):583-593.
  

• Selectivity of mRNA degradation by autophagy in yeast
  Makino S, Kawamata T, Iwasaki S, Ohsumi Y.
  Nat Commun., 2021 Apr 19;12(1):2316. *Recommended in Faculty Opinions
  

2020

• Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion
  Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, Sugita Y, Nomura N, Iwata S, Ohsumi Y, Fujimoto T, Nakatogawa H, Kikkawa M, Noda NN.
  Nat Struct Mol Biol., 2020 Dec;27(12):1185-1193.
  

• Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism.
  May AI, Prescott M, Ohsumi Y.
  Nat Commun., 2020 Oct 7;11(1):5052.
  

• TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes.
  Tomioka Y, Kotani T, Kirisako H, Oikawa Y, Kimura Y, Hirano H, Ohsumi Y, Nakatogawa H.
  J Cell Biol, 2020, 219(7):e201910063 301–305
  

• Phase separation organizes the site of autophagosome formation.
  Fujioka Y, Alam JM, Noshiro D, Mouri K, Ando T, Okada Y, May AI, Knorr RL, Suzuki K, Ohsumi Y, Noda NN
  Nature, 2020, 578, 301–305
  

• Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates.
  Yamasaki A, Alam JM, Noshiro D, Hirata E, Fujioka Y, Suzuki K, Ohsumi Y, Noda NN
  Mol. Cell, 2020, 77, 1163-1175
  

• Autophagy Increases Zinc Bioavailability to Avoid Light-Mediated ROS Production under Zn Deficiency.
  Shinozaki D, Merkulova EA, Naya L, Horie T, Kanno Y, Seo M, Ohsumi Y, Masclaux Daubresse C, Yoshimoto K.
  Plant Physiol., 2020, 182, 1284-1296
  

review

• Mitotic Phosphorylation of the ULK Complex Regulates Cell Cycle Progression.
  Yamasaki A, Jin Y, Ohsumi Y
  PLoS Biol., 2020, 18(6):e3000718.
  

2019

• Atg2 mediates direct lipid transfer between membranes for autophagosome formation.
  Osawa T, Kotani T, Kawaoka T, Hirata E, Suzuki K, Nakatogawa H, Ohsumi Y, Noda NN*.
  Nat. Struct. Mol. Biol.,2019, 26, 281–288
  

• Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
  Harada K**, Kotani T**, Kirisako H, Sakoh-Nakatogawa M, Oikawa Y, Kimura Y, Hirano H, Yamamoto H, Ohsumi Y, Nakatogawa H*., (**these authors contributed equally to this work)
  eLife,2019, 8, e43088
  

• Analysis of autophagy activated during changes in carbon source availability in yeast cells
  Iwama R, Ohsumi Y.
  J. Biol. Chem., 2019, 294, 5590-5603.
  

2018

• The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation.
  Kotani T, Kirisako H, Koizumi M, Ohsumi Y, Nakatogawa H.
  Proc. Natl. Acad. Sci. USA., 2018, 115, 10363-10368.
  

• Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein
  Liu XM, Yamasaki A, Du XM, Coffman VC, Ohsumi Y, Nakatogawa H, Wu JQ, Noda NN, Du LL.
  eLife, 2018, 7, e41237.
  

• Atg7 activates an autophagy-essential ubiquitin-like protein Atg8 through multi-step recognition
  Yamaguchi M, Satoo K, Suzuki H, Fujioka Y, Ohsumi Y, Inagaki F, Noda NN.
  J. Mol. Biol., 2018, 430, 249-257.
  

review

• Unveiling the molecular mechanisms of plant autophagy - from autophagosomes to vacuoles in plants
  Yoshimoto K, Ohsumi Y.
  Plant Cell Physiol., 2018, 59, 1337-1344.
  

2017

• Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression
  Adachi A, Koizumi M, Ohsumi Y.
  J. Biol. Chem., 2017, 292, 19905-19918.
  

• Recycling of iron via autophagy is critical for the transition from glycolytic to respiratory growth
  Horie T, Kawamata T, Matsunami M, Ohsumi Y.
  J. Biol. Chem., 2017, 292, 8533-8543. [Faculty of 1000]
  

• Zinc starvation induces autophagy in yeast
  Kawamata T, Horie T, Matsunami M, Sasaki M, Ohsumi Y.
  J. Biol. Chem., 2017, 292, 8520-8530. [editor’s pick up]
  

• Functional identification of AtAVT3, a family of vacuolar amino acid transporters, in Arabidopsis
  Fujiki Y, Teshima H, Kashiwao S, Kawano-Kawada M, Ohsumi Y, Kakinuma Y, Sekito T.
  FEBS Lett., 2017, 591, 5-15.
  

review

• Recycling of trace metals by the bulk autophagy in the budding yeast, Saccharomyces cerevisiae
  Horie T, Kawamata T, Ohsumi Y.
  J. Adv. Nutr. Hum. Metab., 2017, 3, e1602.
  

2016

• The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes
  Yamamoto H, Fujioka Y, Suzuki SW, Noshiro D, Suzuki H, Kondo-Kakuta C, Kimura Y, Hirano H, Ando T, Noda NN & Ohsumi Y
  Dev. Cell., 2016, 38, 86-99.
  

• Structural basis for receptor-mediated selective autophagy of aminopeptidase I aggregates
  Yamasaki A, Watanabe Y, Adachi W, Suzuki K, Matoba K, Kirisako H, Kumeta H, Nakatogawa H, Ohsumi Y, Inagaki F, Noda NN*
  Cell Rep., 2016, 16, 19-27.
  

2015

• The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
  Yamamoto H, Shima T, Yamaguchi M, Mochizuki Y, Hoshida H, Kakuta S, Kondo-Kakuta C, Noda NN, Inagaki F, Itoh T, Akada R, Ohsumi Y
  J. Biol. Chem., 2015, 290, 29506-29518.
  

• Phospholipid methylation controls Atg32‐mediated mitophagy and Atg8 recycling
  Sakakibara K. Eiyama A. Suzuki SW. Sakoh‐Nakatogawa M. Okumura N. Tani M. Hashimoto A. Nagumo S. Kondo‐Okamoto N. Kondo‐Kakuta C. Asai E. Kirisako H. Nakatogawa H. Kuge O. Takao T. Ohsumi Y. Okamoto K.
  EMBO J., 2015, 34, 2703-2719.
  

• The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation.
  Fei-Fei Yu. Imamura Y. Ueno M. Suzuki SW. Ohsumi Y. Yukawa M. Tsuchiya E.
  Biochem Biophys Res Commun., 2015, 464, 1248-1253.
  

• Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
  Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui , Ueda H, Akazawa Y, Nakayama H, Taneike M, MisakaT, Omiya S, Ajay Shah, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K
  Nat. Commun., 2015, 6, 7527.
  

• Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus.
  Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y,　Nakatogawa H
  Nature., 2015, 522, 359-362.
  

• Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation.
  Suzuki SW, Yamamoto H, Oikawa Y, Kondo-Kakuta C, Kimura Y, Hirano H, Ohsumi Y
  Proc. Natl. Acad. Sci. USA., 2015, 112, 3350-3355.
  

• Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes.
  Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H*, Ohsumi Y*
  FEBS Lett., 2015, 589, 744-749.
  

• Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast.
  Huang H*, Kawamata T*, Horie T, Tsugawa H, Nakayama Y, Ohsumi Y**, Fukusaki E**
  EMBO J., 2015, 34, 154-168.
  *These authors contributed equally to this work. ** Corresponding authors.

• A novel role for 12/15-lipoxygenase in regulating autophagy
  Morgan AH, Hammond VJ, Sakoh-Nakatogawa M, Ohsumi Y, Thomas CP, Blanchet F, Piguet V, Kiselyov K, O'Donnell VB.
  Redox Biol., 2015, 4, 40-47.
  

review

• オートファジー研究の歴史と今後の展開
  大隅良典
  「呼吸器疾患とオートファジー」 THE LUNG perspectives Vol.23, No.2, 127-130 (2015).
  

• 酵母オートファジー　最近の動向
  川俣　朋子、大隅良典
  「セミナー室 / 広がるオートファジーの世界」 化学と生物Vol.53. No1, 51-57 (2015).
  

2014

• Membrane morphology is actively transformed by covalent binding of the protein Atg8 to PE-lipids.
  Knorr RL, Nakatogawa H, Ohsumi Y, Lipowsky R, Baumgart T, Dimova R.
  PLoS One., 2014, 9, e115357.
  

• Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions.
  Mochida K, Ohsumi Y, Nakatogawa H.
  FEBS Lett., 2014, 588, 3862-3869.
  

• Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins.
  Tanaka C, Tan LJ, Mochida K, Kirisako H, Koizumi M, Asai E, Sakoh-Nakatogawa M, Ohsumi Y, Nakatogawa H
  J. Cell Biol., 2014, 207, 91-105.
  

• Structural basis of starvation-induced assembly of the autophagy initiation complex
  Fujioka Y*, Suzuki SW*, Yamamoto H*, Kondo-Kakuta C, Kimura Y, Hirano H, Akada R, Inagaki F, Ohsumi Y**, Noda NN**
  Nat. Struct. Mol. Biol., 2014, 21, 513-521.
  * These authors contributed equally to this work. ** Corresponding authors.

• Proteomic profiling of autophagosome cargo in Saccharomyces cerevisiae.
  Suzuki K, Nakamura S, Morimoto M, Fujii K, Noda NN, Inagaki F, Ohsumi Y
  PLoS One, 2014, 9, e91651.
  

• Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries.
  Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T
  Nat. Commun., 2014, 5, 3207.
  

• Organ-specific quality control of plant peroxisomes is mediated by autophagy.
  Yoshimoto K, Shibata M, Kondo M, Oikawa K, Sato M, Toyooka K, Shirasu K, Nishimura M, Ohsumi Y
  J. Cell Sci., 2014, 127, 1161-1168.
  

review

• Autophagy: close contact keeps out the uninvited
  Nakatogawa H, Ohsumi Y
  Curr. Biol. 2014, 24, R560-562.
  

• Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality
  Shibata M, Oikawa K, Yoshimoto K, Goto-Yamada S, Mano S, Yamada K, Kondo M, Hayashi M, Sakamoto W, Ohsumi Y, Nishimura M
  Autophagy, 2014, 10, 936-937.
  

• Different phosphatidylinositol 3-phosphate asymmetries in yeast and mammalian autophagosomes revealed by a new electron microscopy technique.
  Fujimoto T, Yamamoto H, Ohsumi Y
  Autophagy, 2014, 10, 933-935.
  

• Historical landmarks of autophagy research.
  Ohsumi Y
  Cell Res., 2014, 24, 9-23.
  

2013

• Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis.
  Shibata M, Oikawa K, Yoshimoto K, Kondo M, Mano S, Yamada K, Hayashi M, Sakamoto W, Ohsumi Y, Nishimura M..
  Plant Cell, 2013, 25, 4967-4983.

• Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.
  Araki Y, Ku WC, Akioka M, May AI, Hayashi Y, Arisaka F, Ishihama Y, Ohsumi Y.
  J. Cell Biol., 2013, 203, 299-313.

• Two-Colored Fluorescence Correlation Spectroscopy Screening for LC3-P62 Interaction Inhibitors.
  Tsuganezawa K, Shinohara Y, Ogawa N, Tsuboi S, Okada N, Mori M, Yokoyama S, Noda NN, Inagaki F, Ohsumi Y, Tanaka A.
  J. Biomol. Screen., 2013, 18, 1103-1109.

• Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
  Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H, Ohsumi Y.
  J. Cell Sci., 2013, 126, 2534-2544.

• Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site.
  Sakoh-Nakatogawa M, Matoba K, Asai E, Kirisako H, Ishii J, Noda NN, Inagaki F, Nakatogawa H, Ohsumi Y.
  Nat. Struct. Mol. Biol., 2013, 20, 433-439.

• Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation.
  Noda NN, Fujioka Y, Hanada T, Ohsumi Y, Inagaki F.
  EMBO Rep., 2013, 14, 206-211.

review

• ユビキチン様タンパク質Atg12-Atg5結合体はAtg3の活性中心の再編成をひき起こしその酵素活性を上昇させる
  中戸川万智子、中戸川 仁、大隅良典
  ライフサイエンス新着論文レビュー
  

• 酵母が映し出すオートファゴソーム形成機構の最新像と未解決の重要課題
  中戸川 仁、大隅良典
  「命名から50年 オートファジーで解明した謎，解明したい謎」 実験医学 31, 1348-1354 (2013).

2012

• Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.
  Yamaguchi M, Matoba K, Sawada R, Fujioka Y, Nakatogawa H, Yamamoto H, Kobashigawa Y, Hoshida H, Akada R, Ohsumi Y, Noda NN, Inagaki F.
  Nat. Struct. Mol. Biol., 2012, 19, 1250-1256.

• Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site.
  Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y.
  J. Biol. Chem., 2012, 287, 44261-44269.

• Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18.
  Watanabe Y, Kobayashi T, Yamamoto H, Hoshida H, Akada R, Inagaki F, Ohsumi Y, Noda NN.
  J. Biol. Chem., 2012, 287, 31681-31690.

• Atg9 vesicles are an important membrane source during early steps of autophagosome formation.
  Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y.
  J. Cell Biol., 2012, 198, 219-233.
  

• The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.
  Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y.
  J. Biol. Chem., 2012, 287, 28503-28507.

• Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.
  Kobayashi T, Suzuki K, Ohsumi Y.
  FEBS Lett., 2012, 586, 2473-2478.

• Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.
  Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, Akada R, Ohsumi Y, Inagaki F.
  Structure, 2012, 20, 1244-1254.
  

• Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.
  Noda NN*, Kobayashi T*, Adachi W, Fujioka Y, Ohsumi Y, Inagaki F.
  J. Biol. Chem., 2012, 287, 16256-16266.
  * These authors contributed equally to this work.
  

• Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
  Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, Hashimoto A, Inagaki F, Ohsumi Y, Okamoto K.
  J. Biol. Chem., 2012, 287,10631-10638.
  

• Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.
  Nakatogawa H, Ishii J, Asai E, Ohsumi Y.
  Autophagy, 2012, 8, 177-186.
  

review

• Atg4 proteases in autophagy.
  Nakatogawa H, Ohsumi Y.
  Handbook of Proteolytic Enzymes, 3rd Edn., 2012, 2138-2142.

• SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy.
  Nakatogawa H, Ohsumi Y.
  Methods Mol. Biol., 2012, 832, 519-529.

• オートファジーを長き眠りからめざめさせた酵母
  荒木保弘、大隅 良典
  ライフサイエンス領域融合レビュー 1, e005. (2012)

2011

• Structural basis of Atg8 activation by a homodimeric E1, Atg7.
  Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F.
  Mol. Cell, 2011, 44, 462-475.

• Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae.
  Suzuki K, Morimoto M, Kondo C, Ohsumi Y.
  Dev. Cell, 2011, 21, 358-365.

• Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction.
  Suzuki SW, Onodera J, Ohsumi Y.
  PLoS ONE, 2011, 6, e17412.

review

• The role of Atg proteins in autophagosome formation.
  Mizushima N, Yoshimori T, Ohsumi Y.
  Annu. Rev. Cell Dev. Biol., 2011, 27, 107-132.

• Atg14, a key player in orchestrating autophagy.
  Obara K, Ohsumi Y.
  Int. J. Cell Biol., 2011, 2011, 713435.

• PtdIns 3-kinase orchestrates autophagosome formation in yeast.
  Obara K, Ohsumi Y.
  J. Lipids, 2011, 2011, 498768.

• オートファジーにおける膜形成のダイナミクスと分子メカニズム
  中戸川 仁、大隅 良典
  実験医学増刊 細胞内のリノベーション機構　タンパク質分解系による生体制御
  29, 120-126. (2011)
  

2010

• Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by ATG19 and ATG34.
  Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F.
  J. Biol. Chem, 2010, 285, 30026-30033.

• Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, ATG34.
  Suzuki K, Kondo C, Morimoto M, Ohsumi Y.
  J. Biol. Chem, 2010, 285, 30019-30025.

• Autophagy-related protein (Atg) 8-family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.
  Yamaguchi M, Noda NN, Nakatogawa H, Kumeta H, Ohsumi Y, Inagaki F.
  J. Biol. Chem, 2010, 285, 29599-29607.

• The NMR structure of the autophagy-related protein Atg8.
  Kumeta H, Watanabe M, Nakatogawa H, Yamaguchi M, Ogura K, Adachi W, Fujioka Y, Noda NN, Ohsumi Y, Inagaki F.
  J. Biomol. NMR, 2010, 47, 237-241.

• Tor directly controls the Atg1 kinase complex to regulate autophagy.
  Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y.
  Mol. Cell Biol., 2010, 30, 1049-1058.
  

• The dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy.
  Fujioka Y, Noda NN, Nakatogawa H, Ohsumi Y, Inagaki F.
  J. Biol. Chem., 2010, 285, 1508-1515.
  

review

• The TOR-mediated regulation of autophagy in the yeast, Saccharomyces cerevisiae.
  Kamada Y, Ohsumi Y.
  The Enzymes, 2010, 28, 143-165.
• Current knowledge of the pre-autophagosomal structure (PAS).
  Suzuki K, Ohsumi Y.
  FEBS lett., 2010, 584, 1280-1286.

• Atg8-family interacting motif crucial for selective autophagy.
  Noda NN, Ohsumi Y, Inagaki F.
  FEBS lett., 2010, 584, 1379-1385.

2009

• Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis.
  Yoshimoto K, Jikumaru Y, Kamiya Y, Kusano M, Consonni C, Panstruga R, Ohsumi Y, Shirasu K.
  Plant Cell, 2009, 21, 2914-2927.
  

• Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
  Kabeya Y, Noda NN, Fujioka Y, Suzuki K, Inagaki F, Ohsumi Y.
  Biochem. Biophys. Res. Comm, 2009, 389, 612-615.
  

• Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.
  Okamoto K*, Kondo-Okamoto N*, Ohsumi Y.
  Dev. Cell, 2009, 17, 87-97.
  * These authors contributed equally to this work.
  

• Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.
  Watanabe Y, Noda NN, Honbou K, Suzuki K, Sakai Y, Ohsumi Y, Inagaki F.
  Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2009, 65, 571-573.
  

• The structure of Atg4B-LC3 complex reveals the mechanism of LC3-processing and delipidation during autophagy.
  Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
  EMBO J., 2009, 28, 1341-1350.
  

• The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation.
  Hanada T, Satomi Y, Takao T, Ohsumi Y.
  FEBS Lett., 2009, 583, 1078-1083.
  

• OsATG10b, an autophagosome component, is needed for cell survival against oxidative stresses in rice.
  Shin JH, Yoshimoto K, Ohsumi Y, Jeon JS, An G.
  Mol Cells., 2009, 27, 67-74.
  

• Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
  Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y.
  Genes Cells, 2009, 14, 525-538.
  

• Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae.
  Kageyama T, Suzuki K, Ohsumi Y.
  Biochem. Biophys. Res. Comm., 2009, 378, 551-557.
  

• Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves.
  Wada S, Ishida H, Izumi M, Yoshimoto K, Ohsumi Y, Mae T, Makino A.
  Plant Physiol., 2009, 149, 885-893.
  

review

• A landmark protein essential for mitophagy.
  Okamoto K, Kondo-Okamoto N, Ohsumi Y.
  Autophagy, 2009, 5, 1203-1206.

• Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y.
  Nat. Rev. Mol. Cell Biol., 2009, 10, 458-467.

• ATG Systems from the Protein Structural Point of View.
  Noda NN, Ohsumi Y, Inagaki F.
  Chem Rev., 2009, 109, 1587-1598.
  

• 出芽酵母オートファジー因子の機能
  山本 林、大隅 良典
  実験医学 27, 2924-2929. (2009)
  

2008

• Structural basis of target recognition by Atg8/LC3 during selective autophagy.
  Noda NN*, Kumeta H*, Nakatogawa H*, Satoo K, Adachi W, Ishii J, Fujioka Y, Ohsumi Y, Inagaki F.
  Genes Cells, 13, 1211-1218.
  * These authors contributed equally to this work.
  

• Crystallization of the coiled-coil domain of Atg16 essential for autophagy.
  Fujioka Y, Noda NN, Matsushita M, Ohsumi Y, Inagaki F.
  Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2008, 64, 1046-1048.
  

• Mobilization of Rubisco and stromal-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process.
  Ishida H, Yoshimoto K, Izumi M, Reisen D, Yano Y, Makino A, Ohsumi Y, Hanson MR, Mae T.
  Plant Physiol., 2008, 148, 142-155.
  

• The Atg18-Atg2 complex is recruited to autophagic membranes via PtdIns(3)P and exerts an essential function.
  Obara K, Sekito T, Niimi K, Ohsumi Y.
  J. Biol. Chem., 2008, 283, 23972-23980.
  

• Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8.
  Oh-oka K, Nakatogawa H, Ohsumi, Y.
  J. Biol. Chem., 2008, 283, 21847-21852.
  

• The yeast Tor signaling pathway is involved in G2/M transition via Polo-kinase.
  Nakashima A, Maruki Y, Imamura Y, Kondo C, Kawamata T, Kawanishi I, Takata H, Matsuura A, Lee KS, Kikkawa U, Ohsumi Y, Yonezawa K, Kamada Y.
  PLoS ONE, 2008, 3, e2223.
  

• Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in S. cerevisiae.
  Obara K*, Noda T*, Niimi K, Ohsumi Y.
  Genes Cells, 2008, 13, 537-547.
  * These authors contributed equally to this work.
  

• Organization of the pre-autophagosomal structure responsible for autophagosome formation.
  Kawamata T*, Kamada Y*, Kabeya Y, Sekito T, Ohsumi Y.
  Mol. Biol. Cell, 2008, 19, 2039-2050.
  * These authors contributed equally to this work.
  

• Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free-interface diffusion method.
  Noda NN, Fujioka Y, Ohsumi Y, Inagaki F.
  J. Synchrotron Radiat., 2008, 15, 266-268.
  

• PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans.
  Hu G, Hacham M, Waterman SR, Panepinto J, Shin S, Liu X, Gibbons J, Valyi-Nagy T, Obara K, Jaffe HA, Ohsumi Y, Williamson PR.
  J. Clin. Invest., 2008, 118, 1186-1197.
  

• In vitro reconstitution of plant ATG8 and ATG12 conjugation systems essential for autophagy.
  Fujioka Y, Noda NN, Fujii K, Yoshimoto K, Ohsumi Y, Inagaki F.
  J. Biol. Chem., 2008, 283, 1921-1928.
  

review

• Dynamics and function of PtdIns(3)P in autophagy.
  Obara K, Ohsumi Y.
  Autophagy, 2008, 4, 952-954.
  

• Lipidation of Atg8: How is substrate specificity determined without a canonical E3 enzyme?
  Nakatogawa H, Oh-oka K, Ohsumi Y.
  Autophagy, 2008, 4, 911-913.
  

• Novel families of vacuolar amino acid transporters.
  Sekito T, Fujiki Y, Ohsumi Y, Kakinuma Y.
  IUBMB Life, 2008, 60, 519-525.
  

• Starved cells eat ribosomes.
  Nakatogawa H, Ohsumi Y.
  Nat. Cell Biol., 2008, 10, 505-507.
  

• 出芽酵母のオートファジー －分子機構研究の最前線
  中戸川 仁、大隅 良典　
  蛋白質 核酸 酵素 増刊 「メンブレントラフィックの奔流」 大野 博司, 吉森 保 編 53, 2099-2105. (2008)
  

• オートファジーの膜動態を巡る謎
  小原 圭介、大隅 良典
  生化学 80, 215-223. (2008)
  

• 細胞質の隔離と輸送に特化したオルガネラ：オートファゴソームの構築機構
  中戸川 仁、大隅 良典
  膜 33, 2-8. (2008)
  

• 酵母オートファジーの誘導機構の研究
  鎌田 芳彰、川俣 朋子、大隅 良典
  実験医学 増刊 「細胞内の輪廻転生 タンパク質の分解機構」 田中 啓二 編 26, 141-145. (2008)
  

2007

• The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
  Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y.
  J. Biol. Chem., 2007, 282, 37298-37302.
  

• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.
  Nakatogawa H, Ichimura Y, Ohsumi Y.
  Cell, 2007, 130, 165-178.　　プレスリリース：基生研 / JST
  
• Crystallization and preliminary X-ray analysis of Atg10.
  Yamaguti M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F.
  Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007, 63, 443-445.

• Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.
  Kabeya Y, Kawamata T, Suzuki K, Ohsumi Y.
  Biochem. Biophys. Res. Comm., 2007, 356, 405-410.

• An Arabidopsis homolog of Yeast ATG6/VPS30 is essential for pollen germination.
  Fujiki Y, Yoshimoto K, Ohsumi Y.
  Plant Physiology, 2007, 143, 1132-1139.

• The crystal structure of ATG3, an autophagy-related E2 enzyme that mediates ATG8 lipidation.
  Yamada Y, Suzuki NN, Hanada T, Ichimura Y, Kumeta H, Fujioka Y, Ohsumi Y, Inagaki F.
  J Biol Chem., 2007, 282, 8036-8043.

• Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
  Adachi W, Suzuki NN, Fujioka Y, Suzuki K, Ohsumi Y, Inagaki F.
  Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007, 63, 200-203.

• Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex.
  Satoo K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
  Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007, 63, 99-102.

• Structure of ATG5*ATG16, a complex essential for autophagy.
  Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F.
  J Biol Chem., 2007, 282, 6763-6772.

• Hierarchy of Atg proteins in pre-autophagsomal structure organization.
  Suzuki K, Kubota Y, Sekito T, Ohsumi Y.
  Genes Cells, 2007,12, 209-218.
  

review

• Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae.
  Suzuki K, Ohsumi Y.
  FEBS Lett. 2007, 581, 2156-2161.
  

2006

• AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells.
  Inoue Y, Suzuki T, Hattori M, Yoshimoto K, Ohsumi Y, Moriyasu Y.
  Plant Cell Physiol. 2006, 47,1641-1652.

• Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy.
  Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F.
  Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 2006, 62, 1021-1023.

• Crystallization and preliminary X-ray analysis of Atg3.
  Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
  Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 2006, 62, 1016-1017.
  

• Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.
  Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z.
  EMBO Rep., 2006, 7, 635-642.

• Assortment of phosphatidylinositol 3-kinase complexes - Atg14p directs association of complex I to the pre-autophagosomal structure in S. cerevisiae -.
  Obara K, Sekito T, Ohsumi Y.
  Mol. Biol. Cell, 2006, 17, 1527-1539.

• Organelle degradation during the lens and erythroid differentiation is independent of autophagy.
  Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N.
  Biochem. Biophys. Res. Comm., 2006 Jan 13;339(2):485-489.
  

review

• Protein turnover.
  Ohsumi Y.
  IUBMB Life, 2006, 58 (5-6): 363-369.

• Autophagy in development and stress responses of plants.
  Bassham DC, Laporte M., Marty F, Moriyasu Y, Ohsumi Y, Olsen LJ, Yoshimoto K.
  Autophagy, 2006, 2 (1): 2-11.

• ユビキチン-プロテアソーム系とオートファジー
  田中啓二, 大隅良典　編集
  蛋白質 核酸 酵素 51(10), 2006.
  概論　・・・・・・・・・・・・・・・・・・・・・・・・・・・pp.1444-1447.
  大隅良典
  酵母のオートファジー関連遺伝子　・・・・・・・・・・・・・・pp.1453-1456.
  大隅良典
  オートファゴソームを紡ぎ出す5つのAtg蛋白質群　・・・・・・・pp.1457-1463.
  中戸川 仁、花田孝雄、鎌田芳彰、小原圭介、関藤孝之
  形態学的手法を用いたAtg蛋白質群の総合的理解　・・・・・・・pp.1464-1468.
  鈴木邦律
  小胞体とオートファジー　・・・・・・・・・・・・・・・・・・pp.1469-1473.
  濱崎万穂、大隅良典
  酵母におけるオートファジーの生理的役割と飢餓応答戦略　・・・pp.1499-1502.
  小野寺 純、大隅良典
  植物オートファジー研究の新展開－植物のatg変異体　・・・・・pp.1532-1536.
  吉本光希
  オートファジー用語解説　・・・・・・・・・・・・・・・・・・pp.1551-1553.
  水島 昇、鈴木邦律

2005

• Characterization of a novel autophagy-specific gene, ATG29.
  Kawamata T, Kamada, Y, Suzuki K, Kuboshima N, Akimatsu H, Oota S, Ohsumi M, Ohsumi Y.
  Biochem. Biophys. Res. Comm., 2005, 338, 1884-1889.
  

• Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.
  Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
  J. Biol. Chem. 2005 Dec 2;280(48):40058-65.
  

• Autophagy is required for maintenance of amino acids levels and protein synthesis under nitrogen starvation.
  Onodera J, Ohsumi Y.
  J. Biol. Chem. 2005 Sep;9(280):31582-31586.
  

• Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
  Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y.
  Mol. Cell. Biol. 2005 Aug;25(16):7239-7248.
  

• Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death.
  Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Ohsumi Y, Jung YK.
  J. Biol. Chem. 2005 May 27;280(21):20722-9.
  

• Structure-Function Relationship of Atg12, a Ubiquitin-Like Modifier Essential for Autophagy
  Hanada T, Ohsumi Y.
  Autophagy, July/August/September; 1(2):110-118.
  

• The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy
  Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F.
  Autophagy, July/August/September; 1(2):119-126.
  

• Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.
  Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T.
  J. Cell Biol. 2005 May 9;169(3):425-34.

• Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy.
  Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y.
  Mol. Biol. Cell, 2005 May,16, 2544-2553.

• Starvation Triggers the Delivery of the Endoplasmic Reticulum to the Vacuole via Autophagy in Yeast.
  Hamasaki M, Noda T, Baba M, Ohsumi Y.
  Traffic, 2005 Jan;6(1):56-65.
• A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae.
  Shimazu M, Sekito T, Akiyama K, Ohsumi Y, Kakinuma Y.
  J Biol Chem., 2005 Feb 11;280(6):4851-7.
  

• A Sorting Nexin PpAtg24 Regulates Vacuolar Membrane Dynamics during Pexophagy via Binding to Phosphatidylinositol-3-Phosphate.
  Ano Y, Hattori T, Oku M, Mukaiyama H, Baba M, Ohsumi Y, Kato N, Sakai Y.
  Mol Biol Cell, 2005 Feb;16(2):446-57.
  

review

• 植物のオートファジー
  吉本光希, 大隅良典
  細胞工学 24(6), 593-596. 2005.

• オートファジーにおけるリン脂質の役割
  一村義信, 大隅良典
  実験医学増刊 23(6) 2005. ダイナミックに新展開する脂質研究

2004

• The role of autophagy during the early neonatal starvation period.
  Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N.
  Nature, 2004 Dec 23;432(7020):1032-6.

• Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy.
  Yoshimoto K, Hanaoka H, Sato S, Kato T, Tabata S, Noda T, Ohsumi Y.
  Plant Cell, 2004 Nov;16(11):2967-83.

• Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae.
  Suzuki K, Noda T, Ohsumi Y.
  Yeast, 2004 Sep 27;21(12):1057-65.

• In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy.
  Ichimura Y, Imamura Y, Emoto K, Umeda M, Noda T, Ohsumi Y.
  J. Biol. Chem. 2004 Sep 24;279(39):40584-92.

• The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8.
  Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
  Genes. Cells 2004 Jul;9(7):611-8.

• apg15-1, a UGA mutant allele in the Saccharomyces cerevisiae APG16 gene, and its suppression by a cytoplasmic factor.
  Okazaki H, Ono B, Ohsumi Y, Ohsumi M.
  Biosci Biotechnol Biochem., 2004 Jul;68(7):1541-8.
  

• Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast.
  Ichimura T, Kubota H, Goma T, Mizushima N, Ohsumi Y, Iwago M, Kakiuchi K, Shekhar HU, Shinkawa T, Taoka M, Ito T, Isobe T.
  Biochemistry 2004 May 25;43(20):6149-58.

• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation>
  Kabeya Y, Mizushima N,Yamamoto A, Oshitani-Okamoto S, Ohsumi Y,Yoshimori T
  J. Cell Sci. 2004 Jun 1;117(13):2805-12.

• Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae
  Onodera J, Ohsumi Y
  J. Biol. Chem. 2004 Apr 16;279(16):16071-6.

• In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
  Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y
  Mol. Biol. Cell 2004 Mar;15(3):1101-11.

• Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure
  Mukaiyama H, Baba M, Osumi M, Aoyagi S, Kato N, Ohsumi Y, Sakai Y
  Mol. Biol. Cell 2004 Jan;15(1):58-70.

review

• Cellular recycling system- molecular mechanism of autophagy.
  Cell Growth, Cold Spring Harbor Press, 2004 ipp412-429
  

Ohsumi Y.
• Two ubiquitin-like conjugation systems essential for autophagy.
  Ohsumi Y, Mizuhsima N.
  Semin. Cell Dev. Biol. 2004 Apr;15(2):231-6.

• Autophagy in yeast: a TOR-mediated response to nutrient starvation.
  Kamada Y, Sekito T, Ohsumi Y
  Curr. Top. Microbiol. Immunol. 2004;279:73-84

• 選択的なタンパク質輸送経路としての酵母のオートファジー
  鈴木邦律、大隅良典
  実験医学　Vol.22 No.2（増刊） 150-4. (2004)

2003

• Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
  Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B
  J. Clin. Invest. 2003 Dec;112(12):1809-20.

• A unified nomenclature for yeast autophagy-related genes
  Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y
  Dev. Cell. 2003 Oct;5(4):539-45.

• Crystallization and preliminary X-ray analysis of LC3-I
  Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F
  Acta. Crystallogr. D Biol. Crystallogr. 2003 Aug;59(Pt 8):1464-5.

• Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
  Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, Natsume T, Ohsumi Y, Yoshimori T.
  J. Cell. Sci. 2003 May 1;116(Pt 9):1679-88.

• The early secretory pathway contributes to autophagy in yeast
  Hamasaki M, Noda T, Ohsumi Y.
  Cell Struct. Funct.2003 Feb;28(1):49-54.

review

• Role of the Apg12 conjugation system in mammalian autophagy
  Mizushima N, Yoshimori T, Ohsumi Y.
  Int. J. Biochem. Cell Biol. 2003 May;35(5):553-61.

• The pre-autophagosomal structure (PAS), required for the formation of autophagosome membrane
  Suzuki K, Ohsumi Y.
  Seikagaku. 2003 Jun;75(6):492-9. Japanese. No abstract available.
  

• オートファジー：　植物細胞の液胞とオートファジー
  森安裕二, 吉本光希
  生体の化学, 54, 534-539. 2003.
  

2002

• Mouse Apg10 as an Apg12 conjugating enzyme: Analysis by the conjugation-mediated yeast two-hybrid method
  Mizushima N, Yoshimori T, Ohsumi Y.
  FEBS Lett. 2002 Dec 18:450-454.

• Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae
  Suzuki K,  Kamada  Y,  Ohsumi Y.
  Dev Cell 2002 Dec;(3):815-824.

• Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene
  Hanaoka H, Noda T, Shirano Y, Kato T, Hayashi H, Shibata D, Tabata S, Ohsumi Y.
  Plant Physiol. 2002 Jul;129(3):1181-93.

• The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy
  Suzuki T, Nakagawa M, Yoshikawa A, Sasagawa N, Yoshimori T, Ohsumi Y, Nishino I, Ishiura S, Nonaka I.
  J Biochem (Tokyo). 2002 May;131(5):647-51.

• Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
  Kuma A, Mizushima N, Ishihara N, Ohsumi Y.
  J Biol Chem. 2002 May 24;277(21):18619-25.

• SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation
  Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, Yoshimori T.
  Cell Struct Funct. 2002 Feb;27(1):29-37.

review

• Autophagosome formation in Mammalian cells
  Mizushima N, Ohsumi Y, Yoshimori T
  Cell Struct Funct.  2002 Dec;27(6):421-9.

• Yeast autophagosomes: de novo formation of a membrane structure
  Noda T, Suzuki K, Ohsumi Y.
  Trends Cell Biol.  May;12(5):231-5, 2002

• ユビキチン化に類似した脂質修飾系による膜生成
  野田健司、桐浴隆嘉、 一村義信 、大隅良典
  細胞工学 21: 6, 2002

2001

• The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.
  Suzuki, K.,  Kirisako, T.,  Kamada, Y.,  Mizushima, N.,  Noda, T. and Ohsumi, Y.
  EMBO J. 20, 5971-5981 (2001)

• Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for its fusion to the vacuole.
  Ishihara, T.,  Hamasaki, M., Yokota, S.,  Suzuki, K., Kamada, Y.,  Kihara, A.,  Yoshimori, T., Noda, T., and Ohsumi, Y.
  Mol. Biol. Cell, 12, 3690-3702  (2001)

• Apg2p functions in autophagosome formation on the perivacuolar structure.
  Shintani T, Suzuki K, Kamada Y, Noda T, Ohsumi Y.
  J. Biol Chem.276, 30452-30460 (2001)

• Dissection of Autophagosome Formation using Apg5-deficient Mouse Embryonic Stem Cells
  Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y.,Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y. and Yoshimori, T.
  J. Cell Biol 152, 657-667 (2001)

• Two distinct Vps34 PtdIns 3-kinase Complexes functionin autophagy and CPY sorting in Saccharomyces cevisiae
  Kihara, A., Noda, T., Ishihara, N. and Ohsumi, Y.
  J. Cell Biol 152, 519-530 (2001)

• The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1-activity and E1-E2 complex-formation
  Komatsu,M., Tanida, I., Ueno, T., Ohsumi, M., Ohsumi, Y., and Kominami, E.
  J. Biol. Chem. 276, 9846-9854 (2001)

• Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole
  Kim, J., Kamada, Y., Stromhaug, P.E. Guan, J.,Hefner-Gravinnk, A., Bevan,A., Scott, S. V. Ohsumi, Y., Dunn, Jr., W. A., Klionsky, D.J.
  J. Cell. Biol. 153, 381-396 (2001)

• Beclin-Phsophatidylinositol 3-kinase complex functions at the trans-Golgi Network
  Kihara, A., Kabeya, Y., Ohsumi, Y., and Yoshimori T.
  EMBOReport, 2, 330-335 (2001)

review

• Molecular dissection of autophagy: two ubiquitin-like systems
  Y. Ohsumi
  Nat. Rev. Mol. Cell Biol. 2, 211-216, 2001

• 酵母のオートファジーを司る分子群
  野田健司、鎌田芳彰、大隅良典
  実験医学 19, 288-293, 2001

• 動物細胞オートファジーの分子機構
  水島昇、大隅良典、吉森保
  実験医学 19, 294-299, 2001

• Urm1システム：ユビキチンシステムと硫黄原子転移反応との架け橋
  水島昇、古川和明、野田健司、大隅良典
  実験医学 19, 225-230, 2001

2000

• A ubiquitin-like system mediates protein lipidation
  Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsummi, Y.
  Nature 408, 488-492 (2000)

• Reversible modification regulares the memrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
  Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N.,Yoshimori, T., Ohsumi, M., Noda, T.  and Ohsumi, Y.
  J. Cell Biol 151, 263-276 (2000)

• Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion
  Grote, E, Baba M., Ohsumi, Y., Novick, P.J.
  J. Cell. Biol 151, 453-466 (2000)

• LC3, a mammalian homologue of yeast apg8p is processed and localized in autophagosome membranes
  Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T.
  EMBO. J 19, 5720-5728 (2000)

• Tor-mediated induction of autophgay via an Apg1 protein kinase complex
  Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., Ohsumi, Y
  J. Cell Biol 150, 1507-1513 (2000)

• Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting
  Scott, S. V., Nice III, D. C., Nau, J.J. Weisman< L.S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi,Y., Klionsky, D. J.
  J. Biol. Chem 275, 25840-25849 (2000)

• A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes
  Furukawa K, Mizushima N, Noda T, Ohsumi Y
  J Biol Chem,2000 Mar17; 275 ( 11), 7462-7465

• Apg5p Functions in the Sequestration Step in the Cytoplasm-to-Vacuole Targeting and Macroautophagy Pathways
  George MD, Baba M, Scott SV, Mizushima N, Garrison BS, Ohsumi Y, Klionsky DJ
  Mol Biol Cell 2000 Mar;11(3):969-982

• The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells
  Yoshimori T, Yamagata F, Yamamoto A, Mizushima N, Kabeya Y, Nara A, Miwako I, Ohashi M, Ohsumi M, Ohsumi Y,
  Mol Biol Cell 2000 Feb;11(2):747-763

• Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy Pathways
  Noda  T, Kim J, Huang WP, Baba M, Tokunaga C, Ohsumi Y, and Klionsky DJ,
  J Cell Biol 2000 Feb 7;148(3): 465-480

review

• The yeast vacuole: A paradigm for Plant cell Biologist
  Noda, T., Y. Ohsumi and D. Klionsky
  Annual Plant Reviews 5: 1-191, 2000

• オートファジーとApg12結合システム
  水島昇、大隅良典
  細胞工学19, 286-294, 2000

1999

• Patch clamp studies on V-type ATPase of vacuolar membrane of haploid saccharomyces cerevisiae. Preparation and utilization of a giant cell containing a giant vacuole
  Yabe I, Horiuchi Ki, Nakahara K, Hiyama T, Yamanaka T, Wang PC, Toda K, Hirata A, Ohsumi Y, Hirata R, Anraku Y, Kusaka I
  J Biol Chem 1999 Dec 3;274(49):34903-10

• Formation process of autophagosome is traced with Apg8/Aut7p in yeast.
  Kirisako T, Baba M, Ishihara N, Miyazawa K, Ohsumi M, Yoshimori T, Noda T, Ohsumi Y
  J Cell Biol 1999 Oct 18;147(2):435-46

• Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast.
  Shintani T, Mizushima N, Ogawa Y, Matsuura A, Noda T, Ohsumi Y
  EMBO J 1999 Oct 1;18(19):5234-41

• Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
  Mizushima N, Noda T, Ohsumi Y
  EMBO J 1999 Jul 15;18(14):3888-96

• Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy.
  Tanida I, Mizushima N, Kiyooka M, Ohsumi M, Ueno T, Ohsumi Y, Kominami E
  Mol Biol Cell 1999 May;10(5):1367-79

• A 60 kDa plasma membrane protein changes its localization to autophagosome and autolysosome membranes during induction of autophagy in rat hepatoma cell line, H-4-II-E cells.
  Tagawa Y, Yamamoto A, Yoshimori T, Masaki R, Omori K, Himeno M, Inoue K, Tashiro Y.
  Cell Struct Funct. 1999 Apr;24(2):59-70.

review

• Vacuolar import of proteins and organelles from the cytoplasm
  Klionsky DJ, Ohsumi Y
  Annu. Rev. Cell Dev. Biol. 1999. 15:1-32  

• オートファジー研究における新展開
  水島昇、大隅良典
  蛋白質核酸酵素 Jun;44(7):865-873, 1999

1998

• A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.
  Mizushima N, Sugita H, Yoshimori T, Ohsumi Y
  J Biol Chem 1998 Dec 18;273(51):33889-92

• A protein conjugation system essential for autophagy.
  Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y
  Nature 1998 Sep 24;395(6700):395-8

• Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
  Kametaka S, Okano T, Ohsumi M, Ohsumi Y
  J Biol Chem 1998 Aug 28;273(35):22284-91

• Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast.
  Noda T, Ohsumi Y
  J Biol Chem 1998 Feb 13;273(7):3963-6

• Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
  Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y.
  Cell Struct Funct. 1998 Feb;23(1):33-42.

1997

• Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome.
  Baba M, Osumi M, Scott SV, Klionsky DJ, Ohsumi Y
  J Cell Biol 1997 Dec 29;139(7):1687-95

• Mutational analysis of Csc1/Vps4p: involvement of endosome in regulation of autophagy in yeast.
  Shirahama K, Noda T, Ohsumi Y
  Cell Struct Funct 1997 Oct;22(5):501-9

• The AtVAM3 encodes a syntaxin-related molecule implicated in the vacuolar assembly in Arabidopsis thaliana.
  Sato MH, Nakamura N, Ohsumi Y, Kouchi H, Kondo M, Hara-Nishimura I, Nishimura M, Wada Y
  J Biol Chem 1997 Sep 26;272(39):24530-5

• A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator.
  Gray JV, Ogas JP, Kamada Y, Stone M, Levin DE, Herskowitz I.
  EMBO J. 1997 Aug 15;16(16):4924-37.

• Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.
  Scott SV, Baba M, Ohsumi Y, Klionsky DJ
  J Cell Biol 1997 Jul 14;138(1):37-44

• Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae.
  Matsuura A, Tsukada M, Wada Y, Ohsumi Y
  Gene 1997 Jun 19;192(2):245-50

• Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae.
  Funakoshi T, Matsuura A, Noda T, Ohsumi Y
  Gene 1997 Jun 19;192(2):207-13

• Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae.
  Wada Y, Nakamura N, Ohsumi Y, Hirata A
  J Cell Sci 1997 Jun;110 ( Pt 11):1299-306

• Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.
  Nakamura N, Hirata A, Ohsumi Y, Wada Y
  J Biol Chem 1997 Apr 25;272(17):11344-9

• Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae.
  Nakamura N, Matsuura A, Wada Y, Ohsumi Y
  J Biochem (Tokyo) 1997 Feb;121(2):338-44
  

review

• 酵母における蛋白質分解系としての液胞
  野田健司、大隅良典
  蛋白質核酸酵素, 567, 2325-2334, 1997

～1996

• Vacuolar function in the phosphate homeostasis of the yeast Saccharomyces cerevisiae.
  Shirahama K, Yazaki Y, Sakano K, Wada Y, Ohsumi Y.
  Plant Cell Physiol.1996 Dec;37(8):1090-3.

• Structural and functional analyses of APG5, a gene involved in autophagy in yeast.
  Kametaka S, Matsuura A, Wada Y, Ohsumi Y.
  Gene. 1996 Oct 31;178(1-2):139-43.

• Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
  Scott SV, Hefner-Gravink A, Morano KA, Noda T, Ohsumi Y, Klionsky DJ.
  Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12304-8.

• Autophagy in Tobacco Suspension-Cultured Cells in Response to Sucrose Starvation.
  Moriyasu Y, Ohsumi Y.
  Plant Physiol 1996 Aug;111(4):1233-1241.

• Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method.
  Baba M, Osumi M, Ohsumi Y.
  Cell Struct Funct. 1995 Dec;20(6):465-71.

• Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae.
  Noda T, Matsuura A, Wada Y, Ohsumi Y.
  Biochem Biophys Res Commun. 1995 May 5;210(1):126-32.

• Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations.
  Yorihuzi T, Ohsumi Y
  Yeast 1994 May;10(5):579-94

• Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization.
  Baba M, Takeshige K, Baba N, Ohsumi Y.
  J Cell Biol. 1994 Mar;124(6):903-13.

• Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.
  Tsukada M, Ohsumi Y
  FEBS Lett. 1993 Oct 25;333(1-2):169-74.

• Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction.
  Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y.
  J Cell Biol. 1992 Oct;119(2):301-11